Fig. 5: PTMNavigator supports the analysis of drug dose-dependent perturbation data. | Nature Communications

Fig. 5: PTMNavigator supports the analysis of drug dose-dependent perturbation data.

From: PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways

Fig. 5

A Edited screenshot from PTMNavigator showing an excerpt from the pathway diagram “mTOR Signaling Pathway - hsa04150” and the modified peptides regulated in the Lapatinib experiment of Zecha et al. Note that the authors added the node for EGFR. It is not part of the original pathway diagram but is known to interact with GRB2 and PI3K. The blue borders indicate kinases whose activity was significantly decreased (Score <−0.5, FDR < 0.1) according to RoKAI refinement followed by KSEA analysis. B decryptM curves from the Lapatinib dataset for those peptides that were also significantly downregulated in the Bekker-Jensen data. C decryptM curves with the highest (pEC50 = 7.41) and lowest (pEC50 = 6.37) potency in the mTOR signaling pathway. Source data are provided as a Source Data file.

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