Fig. 6: Extending a canonical pathway with PTMNavigator. | Nature Communications

Fig. 6: Extending a canonical pathway with PTMNavigator.

From: PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways

Fig. 6

A Edited screenshot from PTMNavigator showing an excerpt from the pathway diagram “Regulation of Actin Cytoskeleton – WP51” and the modified peptides regulated in the Refametinib (left) and Mirdametinib (right) decryptM experiments. All regulations are downregulations. B Pathway graph of the Refametinib dataset generated by PHONEMeS. The kinases with decreased activity (determined by RoKAI + KSEA) were used as perturbation targets in the PHONEMeS input. C Proposed manual extension to the diagram “WP51”, created using the “Editing Mode” within PTMNavigator. For illustrative purposes, nodes and edges added by hand are shown in green. Source data for (A, B) are provided as a Source Data file.

Back to article page