Fig. 7: AVX420 activates a transcriptional response to oxidative stress. | Nature Communications

Fig. 7: AVX420 activates a transcriptional response to oxidative stress.

From: Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A2 α for targeted cancer therapy

Fig. 7

a Comparison between fold change and expression in RNA-Seq libraries from CCRF-CEM cells treated for 16 h with 0.5 μM AVX420 or vehicle control. Red and blue dots indicate genes that are expressed differentially with an adjusted P-value < 0.01, while grey dots represent genes that are not. b Top ten (i) oncogenic, and (ii) transcription factor target (C3) gene sets in MSigDB that overlapped with the genes upregulated after 16 h treatment with 0.5 μM AVX420. c Model for the role cPLA2α in inhibitor-sensitive cancers. Cancers which rely on mitochondrial fatty acid oxidation (FAO) for energy derived from oxidative phosphorylation (OXPHOS) have a high oxidative burden. We propose cPLA2α is integral to cancer cell survival in this case by inhibiting iROS accumulation and maintaining epigenetic suppression of programmed cell death. Created in BioRender. Ashcroft, F. (2024) https://BioRender.com/r27a486.

Back to article page