Fig. 4: Fitness of intracellular Leishmania, in macrophages and in mice. | Nature Communications

Fig. 4: Fitness of intracellular Leishmania, in macrophages and in mice.

From: TransLeish: Identification of membrane transporters essential for survival of intracellular Leishmania parasites in a systematic gene deletion screen

Fig. 4

A Overview of the bar-seq timeline for knockout library pooling and infection of hiPSC-Mac and mice. DNA sampling timepoints are marked by blue circles. B–E Fitness scores of TransLeish mutant cell lines for each time point in hiPSC-Mac. F–H Fitness scores of TransLeish mutant cell lines for each time point in mice. Small grey dots represent the transporter mutants, ranked in order of their fitness score, from lowest to highest. Larger dots show parental control cell lines (SBL1-5) and control mutants, as labelled. The source data are provided in Supplementary Data 4.

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