Fig. 5: Transporter mutants with significant loss of fitness in macrophages and mice. | Nature Communications

Fig. 5: Transporter mutants with significant loss of fitness in macrophages and mice.

From: TransLeish: Identification of membrane transporters essential for survival of intracellular Leishmania parasites in a systematic gene deletion screen

Fig. 5

Venn diagram of transporter mutants depleted in samples from macrophages infected for 5 days and mice infected for 3 and 6 weeks (fitness score below 0.5; p < 0.05). A Transporter mutants that showed a significant loss of fitness in all three conditions. B Transporter mutants that showed significant loss of fitness only in mice. C Mutants that showed significant loss of fitness at the final time points in macrophages and mice. Asterisks indicate mutants where gene deletion was incomplete. P-values were calculated using a Mann–Whitney U test; source data are provided in Supplementary Data 4.

Back to article page