Fig. 6: L. mexicana V-ATPase mutants are viable as promastigotes. | Nature Communications

Fig. 6: L. mexicana V-ATPase mutants are viable as promastigotes.

From: TransLeish: Identification of membrane transporters essential for survival of intracellular Leishmania parasites in a systematic gene deletion screen

Fig. 6

A Schematic of V-ATPase subunits identified in L. mexicana, coloured by the genotype of the corresponding mutants. B Gene IDs of L. mexicana V-ATPase subunits. C Barcode proportions of mutants after 24 h of exponential growth in culture. Mutants were grouped into the following categories: ‘All mutants’ represent all non-V-ATPase transporter mutants in the pool (dark grey dots); ‘Controls’ represent the barcoded parental controls (SBL1-5, turquoise dots) and control mutants Δdihydroorotase (light grey dot), ΔIFT88 (white dot) and ΔMBO2 (black dot); ‘V-ATPase components‘ are shown as red dots. Each dot represents the average barcode proportion for one mutant cell line after 24 h (normalised to 0 h). The source data are provided in Supplementary Data 4.

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