Fig. 7: seRNA in vivo diffusion analysis.
From: Selectively expressed RNA molecules as a versatile tool for functionalized cell targeting
a Mice with or without early U87 tumors (day 3) were treated with seRNA plasmids expressing either GFP (top) or ca-Caspase3 (bottom). After an additional two days, mice were sacrificed, and brain tissue samples from indicated positions were taken and tested for seRNA encoding plasmid DNA and expressed seRNA. Figure shows data from single mice, taken from a series of experiments. Same qPCR (DNA) (b) and qRT-PCR (RNA) (c) analysis were performed for indicated organs 2 as well as 7 days after seRNA-ca-Caspase3 brain transfer. For each time point 4 treated and 2 untreated mice were analyzed. Values are given as mean. For the brain as the only organ with detectable seRNA, values are given with s.d. Created with BioRender.com.
