Fig. 5: Application of PACS to time-series human PBMC treatment data.
From: Depth-corrected multi-factor dissection of chromatin accessibility for scATAC-seq data with PACS
a Factor landscape of the PBMC treatment dataset. Here, another layer of factor is the four different treatments, which can also be jointly considered in the model. For demonstration purposes, we only focus on the effect of PMA treatment. The baseline (control) is designated as time 0, with subsequent time points at one hour (time 1) and six hours (time 2) post-treatment. b, c Summaries of chromatin accessibility peaks significantly upregulated or downregulated in response to PMA treatment across different cell types. The full list of differentially accessible peaks can be found in Supplementary Data 16, 17. d, e Heatmaps display significant chromatin accessibility peaks, categorized by upregulation or downregulation, organized by cell type and time point. The color scale (scaled_acc) quantifies the z-score of accessibility.
