Fig. 3: Substrate scope and synthetic transformations.
From: Organocatalytic enantioselective synthesis of double S-shaped quadruple helicene-like molecules
a Substrate scope of (P,P,P,P)-2 and (M,M,M,M)-2. Reaction conditions: 1 (0.02 mmol, 1.0 equiv), catalyst (0.004 mmol, 20 mol%) in 2-MeTHF (2.0 mL) at corresponding temperature for 1.5 h and then N-bromo-phthalimide (NBP) (0.04 mmol, 2.0 equiv) at −60 °C for 2 h. aThe reaction was conducted at -78 °C for 24 h. bThe reaction was conducted in cyclopentyl methyl ether (CPME) at -78 °C for 24 h. b Synthetic transformations of (P,P,P,P)−2a. t-Bu, tert-butyl. TMS, trimethylsilyl. i-Pr, isopropyl.
