Fig. 6: Comparison between Inhibit and Remove datasets.
From: Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface
a Average expression of top markers between Remove (R) and Inhibit (I) datasets over time (h). Dots represent the average expression of the gene at each time point. Top 8 genes consistently higher in Inhibit and Remove were selected. Source data are provided as a Source Data file. b SCENIC Heatmap showing unique regulons for Remove and Inhibit datasets with clusters ordered by timepoint using Tempora. Colour represents average score for the activity of the regulon for each cluster. Grey fields are regulons absent in one of the datasets. All values were mean centred for each regulon. Inhibit regulons were hierarchically clustered and the same order was applied to the Remove dataset to allow for direct comparison of regulon activity. c Heatmap showing expression of detected TGFβ pathway-related genes (defined by GO:0007179) across Inhibit and Remove t24 clusters. Clusters that contain >85% cells from one treatment were selected. Gene list was filtered to include only marker genes (l2fc0.6) for t24 dataset. Genes and clusters were hierarchically clustered. Values were mean centred for each gene. Colour represents average expression of marker gene in a cluster.
