Fig. 6: Model for the Cell-Cycle-Integrated Control of Chr2 Replication in V. cholerae. | Nature Communications

Fig. 6: Model for the Cell-Cycle-Integrated Control of Chr2 Replication in V. cholerae.

From: Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae

Fig. 6

1 Prior crtS replication, ori2 is sequestered by an inhibition complex, formed by RctB multimers bridging 29/39 m sites. RctB oligomerization domain IV is involved in the formation of this nucleoprotein complex. 2 Upon crtS replication, we hypothesize that the second copy of crtS destabilizes the inhibition complex, possibly at the domain IV secondary interface. 3 Ori2 is thus released and the iteron array becomes accessible for RctB binding. This leads to the opening of the DUE, as shown18.

Back to article page