Fig. 2: Methylomes of DNMT3AINS AMLs are similar to DNMT3AWT AMLs, but not to that of DNMT3AR882. | Nature Communications

Fig. 2: Methylomes of DNMT3AINS AMLs are similar to DNMT3AWT AMLs, but not to that of DNMT3AR882.

From: Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication

Fig. 2

a Distribution of average methylation level difference in DMRs identified between DNMT3AR882 and DNMT3AWT AMLs. b Average methylation levels of different DNMT3A mutation subclasses of AMLs around the hypo-DMRs identified between DNMT3AR882 and DNMT3AWT AMLs. c Distribution of average methylation level difference in DMRs identified between different DNMT3A mutation subclsses and normal bone marrow cells using RRBS. d Average methylation levels surrounding the hyper-DMRs in DNMT3AINS (vs normal bone marrow cells) for each DNMT3A mutation subclass. Hypo-DMRs, Hypomethylated DMRs; Hyper-DMRs, Hypermethylated DMRs. In (b, d), shades denote 95% confidence intervals.

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