Fig. 10: The P8 stem loop also interacts with pk-1 through an A-minor motif.
From: Scaffold-enabled high-resolution cryo-EM structure determination of RNA
(A) The organization of the P6, P7, and P8 stems are shown relative to pk-1. P8 consists of numerous noncanonical base pairs and, as a result, exhibits a distorted helical geometry. The minor grooved of P8 and pk-1 can be observed interacting. (B) The conserved E-Loop region of P8 forms through multiple consecutive noncanonical base pairs. This architecture results in a helical geometry capable of forming an A-minor motif with the opposite side of pk-1 relative to the P4/P5 stem loop.
