Fig. 2: Tandem reductive amination-deuteration of p-anisidine with benzaldehydea.
From: Tandem reductive amination and deuteration over a phosphorus-modified iron center
a Catalyst testing, b reaction conversion-time profile, and c proposed reaction pathway. aReaction conditions: 0.25 mmol 1a, 0.25 mmol 1b, 0.2 mol% Fe catalyst (e.g., 20 mg Fe–P–C–800), 90 equiv. D2O (405 µL), 1 mL toluene, 40 bar H2, 140 °C, 24 h. bFeNP/C (Fe–Cellulose-1000) is prepared according to previous work18. The NMR of products 1c + 1 d are shown in Supplementary Figs. 25–26.
