Fig. 5: Substrate scope.

a–c Tandem reductive amination and deuteration of different amino-substituted (hetero)arenes and aldehydes. ^aReaction conditions: 0.25 mmol amino-substituted (hetero)arenes, 0.25 mmol aldehydes, 0.2 mol% Fe catalyst (20 mg Fe–P–C-800), 90 equiv. D₂O (405 µL), 1 mL toluene, 40 bar H₂, 140 °C, 24 h; ^b150 °C; ^cN-benzyl-2,3,4,5,6-pentadeuterioaniline as substrate, H₂O as additive; ^dbenzaldehyde-α-¹³C as substrate; ^e0.5 mmol benzaldehyde; ^f160 °C; ^gcorresponding nitro compound as substrate. Subscripts under product represents isolated yields; the numbers around D represent the deuterium incorporation; the NMR spectra of products can be found in Supplementary Figs. 27–121.