Fig. 6: Applications.
From: Tandem reductive amination and deuteration over a phosphorus-modified iron center
a Selected synthesis of deuterated bio-active and drug molecules: showcasing the applicability of this domino transformationa, b scale-up recycling experiments,d and c HRTEM of used Fe–P–C catalyst after five recycles. aReaction conditions: 0.25 mmol anilines/amines, 0.25 mmol aldehydes, 0.2 mol% Fe catalyst (20 mg Fe–P–C-800), 90 equiv. D2O (405 µL), 1 mL toluene, 40 bar H2, 140 °C, 24 h; b150 °C; creductive amination in toluene for 12 h, then adding D2O for continuing 12 h reaction; d10 mmol p-anisidine 1a, 10 mmol 1b, 1.0 g Fe–P–C-800 catalyst, 40 mL D2O, 150 mL toluene, 60 bar H2, 150 °C, 24 h. Subscripts under products represent isolated yields; the numbers around D represent the deuterium incorporation; the NMR spectra of products can be found in Supplementary Figs. 121–132.
