Fig. 3: Enantioselective synthesis of 1,3-diols.
From: A modular approach to catalytic stereoselective synthesis of chiral 1,2-diols and 1,3-diols
Reaction conditions: 2 (0.2 mmol), 4a (2.0 mmol), NiBr2.DME (10 mol%), L6 (15 mol%), TBADT (5 mol%), K3PO4 (0.30 mmol) in acetone (0.5 mL) and PhCF3 (0.5 mL) under the irradiation of LEDs (10 W, 390 nm) at 25 °C for 60 h. Yields are for isolated and purified products. The ee values were determined by HPLC using a chiral stationary phase and d.r. ratios were determined by 1H NMR analysis.
