Table 1 Optimization of reaction conditions

All reactions were carried out on a 0.2 mmol scale with respect to aryl bromide (2a). Conditions: NiBr₂.DME (10 mol%), chiral ligand L (15 mol%), 2a (0.2 mmol), 1 (1.0 mmol), K₃PO₄ (0.24 mmol), photocatalyst, solvent (2.0 mL, 0.1 M) under the irradiation of LEDs (10 W, 390 nm) at 25 °C for 60 h. Yields are for isolated and purified products. The ee values were determined by HPLC using a chiral stationary phase.
NP no product.
^aThe reaction was performed in EtOAc at 25 °C using PC as photocatalyst and L1 as ligand.
^bThe reaction was performed at −5 °C.
^cAcetone/PhCF₃ (1.0 mL, 0.2 M).

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