Fig. 6: Magnetically reshapable 3D LM MEA.

a Schematic illustration of magnetically reshapable 3D LM MEA. b SEM image (top) and EDS analysis (bottom) of partial magnetic layer on 3D LM electrode. Scale bars, 10 µm. This experiment was independently repeated more than ten times with similar results. c Magnetization of magnetically reshapable 3D LM electrode. d Trajectories of electrode tip during 20 repetitive tilting cycles. The color bar represents the cycle of repetitive tilting. e Magnetic tilting degrees (blue) and displacements (yellow) of the electrode tip for the repetitive cycles. f Expanded detectable area of the single tiltable electrode in various directions. g, h Multi-spot detection of intra-organoid signals by magnetically reshapable 3D LM MEA. SU potential, colored raster plot, and spikeforms when the degree of reshaping (θ) is (g) 8.2° and (h) 15.6° are presented. Scale bars, 50 µV (vertical), 1 s (horizontal) for single unit potential; 20 µV (vertical), 1 ms (horizontal) for spikeforms. Each color of spikeforms represent individual cluster of spikes. LM, liquid metal; MEA, multi-electrode array; SEM, scanning electron microscopy. EDS, energy-dispersive X-ray spectroscopy. SU, single-unit.