Fig. 3: Compared to controls, SOT recipients have lower B-cell plasmablasts and higher EMRA T cells as well as lower SARS-CoV-2 antibody levels at hospitalization.

a Differences in immune cell population frequency measured by CyTOF by SOT recipients (yellow, n = 54) and controls (blue, n = 107). b Box plots highlighting two cell types which differed in frequency between SOT recipients and controls. Boxes show the median and interquartile range (IQR), whiskers were calculated as the 25th percentile minus 1.5 times the IQR and the 75th percentile plus 1.5 times the IQR. P values in (a, b) were calculated with a linear model and Benjamini–Hochberg correction. c Box plot of spike IgG levels measured by area under the curve (AUC) by SOT recipients (n = 86) and controls (n = 172). d Longitudinal dynamics of spike IgG levels (log-transformed AUC) in SOT recipients and controls over the course of hospitalization. The blue and orange lines indicate the generalized additive mixed model fits, and the ribbons indicate the 95% confidence interval of the fits. P values were calculated with c a linear model or d a generalized additive mixed model. The number of patients sampled at each time point is depicted graphically below the X axis of (d). EMRA effector memory re-expressing CD45RA.