Fig. 6: Protective efficacy of VLP-S2 after prime-boost. | Nature Communications

Fig. 6: Protective efficacy of VLP-S2 after prime-boost.

From: Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice

Fig. 6

Virus titers in the lungs of K18-hACE2 mice immunized with two doses of S2 VLPs three days after infection with Pangolin-GD, BANAL-236, WIV1, and XBB (mean ± SD, n = 5 biological replicates). *P < 0.05 (WIV1 challenge group VLP-CoV-1 S2 vs VLP-CoV-1 S2 + VLP-CoV-2 S2: P = 0.0220; XBB.1 challenge group VLP-CoV-1 S2 vs VLP-CoV-1 S2 + VLP-CoV-2 S2: P = 0.0218), ****P < 0.0001. Significance was determined by an ordinary one-way ANOVA and Tukey post hoc multiple comparisons between groups for XBB and WIV1, and by Brown-Forsythe and Welch ANOVA and Games-Howell’s multiple comparisons between groups for BANAL-236 and Pangolin-GD. ● or † indicate data from individual mice. † - No infectious virus was detected in the lungs of immunized mice. The detection limit (dotted line) = 1.3 log10 pfu/g.

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