Fig. 2: The dynamics of gene expression has changed throughout the whole tooth morphogenesis in mouse and hamster. | Nature Communications

Fig. 2: The dynamics of gene expression has changed throughout the whole tooth morphogenesis in mouse and hamster.

From: Comparative transcriptomics in serial organs uncovers early and pan-organ developmental changes associated with organ-specific morphological adaptation

Fig. 2

a Embryo sampling used for expression profiling, in whole tooth germs, tooth tissues (mesenchyme/epithelium) and tooth halves (bucco/lingual). Each embryo provided upper and lower samples. Relative developmental time established from embryonic weight and boundaries for stage homology as in Fig. 1. The morphological stages (as in Fig. 1) indicated are for lower molars. b Principal component analysis (PCA) of 64 whole molar bulk transcriptomes based on 14532 1:1 orthologues. Each symbol is an individual transcriptome with a colour gradient for the embryo’s relative development times. Dotted lines: Stage homology established by morphology is confirmed by transcriptomes and used as boundaries for relative developmental time. c Temporal expression profiles modelled with polynomials for the Fgf10 gene. Distance between pairs of curves is computed for ten time windows (comparison of hamster and mouse upper molars profiles is shown for Fgf10). d Average distance in each window shown for all pairwise comparisons.

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