Fig. 3: m-f-PBPK model snapshot predicted vs. observed steady-state Δ9-THC umbilical venous plasma (UVP) and fetal tissue concentration relative to the corresponding maternal plasma (MP) concentration. | Nature Communications

Fig. 3: m-f-PBPK model snapshot predicted vs. observed steady-state Δ9-THC umbilical venous plasma (UVP) and fetal tissue concentration relative to the corresponding maternal plasma (MP) concentration.

From: Quantification and prediction of human fetal (-)-Δ9-tetrahydrocannabinol/(±)-11-OH-Δ9-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity

Fig. 3

The m-f-PBPK model predicted (*) trimester 3 (T3; GW38) UVP/MP (n = 18) and trimester 2 (T2; GW15) fetal tissue/MP (fetal brain/MP: n = 14; fetal kidney/MP: n = 8; fetal liver/MP: n = 11) fell within the acceptance range (horizontal lines; filled circles denote the median and bars denote the range of the observed values). The m-f-PBPK model predicted values were those at 12 h post Δ9-THC consumption (inhalation or oral) when distributional equilibrium between plasma and tissue Δ9-THC concentration was expected to have been reached (see Supplementary Fig. 4). Source data are provided in Supplementary Tables 3-4.

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