Fig. 4: m-f-PBPK model predicted non-pregnant and gestational age-dependent Δ9-THC/11-OH-THC maternal plasma (MP) concentration-time profiles after daily maternal Δ9-THC inhalation (10 mg) or oral (10 mg) consumption. | Nature Communications

Fig. 4: m-f-PBPK model predicted non-pregnant and gestational age-dependent Δ9-THC/11-OH-THC maternal plasma (MP) concentration-time profiles after daily maternal Δ9-THC inhalation (10 mg) or oral (10 mg) consumption.

From: Quantification and prediction of human fetal (-)-Δ9-tetrahydrocannabinol/(±)-11-OH-Δ9-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity

Fig. 4

When compared to the non-pregnant population, as gestational week (GW) advanced from 15 to 40, A MP Δ9-THC Css,avg and Css,max, after daily Δ9-THC (10 mg; 32 µmol) inhalation, decreased marginally by 4−11% and 0-7%, respectively; B MP Δ9-THC Css,avg and Css,max, after daily Δ9-THC (10 mg; 32 µmol) oral consumption, decreased modestly by 15–28% and 16–28%, respectively. Likewise, there was marginal gestational-age dependent decrease (1-5%) in 11-OH-THC MP Css,avg and Css,max, after both inhalational and oral Δ9-THC consumption. Insets show data truncated to 6 h. Δ9-THC: 1 nM =;0.314 ng/mL; 11-OH-THC: 1 nM = 0.330 ng/mL. Source data are provided as a Source Data file.

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