Fig. 5: m-f-PBPK model predicted gestational age-dependent changes in Δ9-THC/11-OH-THC umbilical venous plasma (UVP) and fetal brain concentration-time profiles after daily maternal inhalation (10 mg; 32 µmol) or oral (10 mg; 32 µmol) consumption of Δ9-THC. | Nature Communications

Fig. 5: m-f-PBPK model predicted gestational age-dependent changes in Δ9-THC/11-OH-THC umbilical venous plasma (UVP) and fetal brain concentration-time profiles after daily maternal inhalation (10 mg; 32 µmol) or oral (10 mg; 32 µmol) consumption of Δ9-THC.

From: Quantification and prediction of human fetal (-)-Δ9-tetrahydrocannabinol/(±)-11-OH-Δ9-tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity

Fig. 5

The maximum Δ9-THC and 11-OH-THC exposure (Css,avg and Css,max) in the (A, C) UVP and (B, D) fetal brain was predicted to be at the earliest gestational week (GW15) for which predictions could be made. This was because the predicted maternal plasma (MP), UVP/MP and fetal brain/MP all decreased with increasing gestational age. Insets show data truncated to 6 h. Δ9-THC: 1 nM = 0.314 ng/mL; 11-OH-THC: 1 nM = 0.330 ng/mL. Source data are provided as a Source Data file.

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