Fig. 2: Routine health records stratify phenome-wide disease onset. | Nature Communications

Fig. 2: Routine health records stratify phenome-wide disease onset.

From: Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats

Fig. 2

a Ratio of incident events in the Top 10% compared with the Bottom 10% of the estimated risk states. Event rates in the Top 10% are higher than in the Bottom 10% for all but one of the 1741 investigated endpoints. Red dots indicate 24 selected endpoints detailed in Fig. 2b. To illustrate, 1053 (2.10%) individuals in the top risk decile for cardiac arrest experienced an event compared with only 59 (0.12%) in the bottom decile, with a risk ratio of 17.85. b Incident event rates for each medical history risk percentile (if medical history was available) for a selection of 24 endpoints. c Cumulative event rates with 95% confidence intervals for the Top 1%, median, and Bottom 1% of risk percentiles in (b) over 15ys. Statistical measures were derived from 502,489 individuals. Individuals with prevalent diseases were excluded from the endpoints-specific analysis. Source data are provided.

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