Fig. 2: mosGILT antibodies decrease P. falciparum and P. berghei oocyst infection prevalence in a membrane-feeding model.

a, b Dot-plots showing the number of P. falciparum oocysts per midgut (a, p = 0.0009; b, p = 0.0007) and infection prevalence (pie charts) (a, p = 0.0048; b, p = 0.0260) from mosquitoes that took a blood meal with a low gametocytemia blood (a, 0.008%) and high gametocytemia blood (b, 0.5%) with a final concentration of 0.2 mg/ml mosGILT (a, n = 66; b, n = 89) or control (a, n = 51; b, n = 78) antibodies. c Dot-plot of P. berghei oocysts counts per midgut (p = 0.0157) and infection prevalence (pie charts) from mosquitoes that took a blood meal from the feeder with 0.2 mg/ml mosGILT (n = 179) or control (n = 152) antibodies. Oocysts were counted seven days post-infected blood meal. Each dot represents the number of oocysts in an individual mosquito midgut. The blue and red horizontal lines indicate the medians for the control and intervention groups, respectively. The thin lines indicate upper and lower quartiles. Low and high P. falciparum experiments were replicated a total of three times. P. berghei experiment was replicated more than three times. Two-Tailed Mann-Whitney was used to determine the significance of oocyst abundance. Fisher’s exact test was used to compare infection prevalence values (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001). Source data are provided as a Source Data file.