Fig. 6: mosGILT antibodies reduce the sporogony of P. berghei in A. gambiae by acting on the oocyst stage of the parasite.

a Illustration of the experimental scheme of a partially infected blood meal (IBM) followed by an antisera blood meal. b Visual representations of mosquitoes that had a complete blood meal (Engorged), partial blood meal (Partial), or no blood meal (Unfed). Mosquitoes that visually matched the partial blood meal status were used in this experimental scheme. c Number of P. berghei oocysts per midgut (p = 0.0001) and infection prevalence (pie charts) (p = 0.0099) of mosquitoes that took a partial IBM followed by a blood meal 48 h later from a GST (IBM + Control; n = 51) or mosGILT antisera (IBM + mosGILT; n = 76) immunized mouse. Oocysts were counted eight days post-IBM. Each dot represents the number of oocysts in an individual mosquito midgut, and the blue and red horizontal lines indicate the medians for the control and intervention groups, respectively. The thin lines indicate upper and lower quartiles. Two experimental replicates were performed. Two-Tailed Mann-Whitney was used to determine the significance of oocyst abundance. Fisher’s exact test was used to compare infection prevalence values (**p ≤ 0.01, ***p ≤ 0.001). Source data are provided as a Source Data file.