Table 3 Comparison of two linear mixed effect models which tested for the association of daily cortisol slope steepness with PedBE Epigenetic Age Acceleration (EAA): one without accounting for estimated BEC proportion (left column) and one with estimated BEC proportion correction (right column)
From: Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research
PedBE EAA without BEC correction | PedBE EAA with BEC correction | |||||
|---|---|---|---|---|---|---|
Predictors | Estimates | CI | P value | Estimates | CI | P value |
(Intercept) | 0.49 | −0.20–1.18 | 0.16 | 0.52 | −0.17–1.20 | 0.134 |
Mean cortisol slope | 1.48 | 0.19–2.47 | 0.024* | 1.4 | 0.28–2.53 | 0.016 |
Random effects | ||||||
a2 | 0.41 | |||||
Too | 0.24twinpairs | 0.23twinpairs | ||||
ICC | 0.37 | |||||
Observations | 41 | 41 | ||||
Marginal R2/ Conditional R2 | 0.12/0.44 | 0.14/0.44 | ||||
AIC | 104.4 | 103.2 | ||||
BIC | 111.2 | 110 | ||||
