Fig. 1: Graphical representation of the study design and analytic flow.
From: Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure
Cross-sectional discovery analyses were performed in the Subclinical Myocardial Abnormalities in HIV Study (SMASH) using linear regression with robust variance. Analyses of HIV serostatus adjusted for sociodemographics, substance use, hepatitis C virus infection, and renal function. Analyses of left atrial size further adjusted for HIV serostatus, body mass index, systolic blood pressure, hypertension medication use, dyslipidemia, and diabetes. Both cross-sectional and longitudinal time-to-incident event analyses were performed among an external population of older people without HIV in the Multi-Ethnic Study of Atherosclerosis (MESA). Cross-sectional analyses of left atrial size were performed using linear regression with robust variance, adjusting for field center, sociodemographics, smoking, body mass index, systolic blood pressure, hypertension medication use, dyslipidemia, diabetes, and renal function. Time-to-event analyses of atrial fibrillation and heart failure were performed using Cox proportional hazards regression, adjusting for the same covariates. Proteome feature counts listed are those associated with indicated outcomes at a false discovery rate < 0.05.
