Table 3 Summary of cross-sectional associations between identified HIV-associated proteomic signature of left atrial size and indexed left atrial volume by age among people without HIV in MESA (n = 1242)

From: Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure

Analysis Sample

Mean (SD) Age

Proteins FDR < 0.05 a

All participants

68 (9)

CKB, CLEC14A, CNTN3, COL4A1, IGFBP2, NOTCH3, NT-proBNP, PDGFRA

Participants ≥ median age

75 (5)

B3GNT7, CLEC14A, COL4A1, CRIM1, CX3CL1, DCTPP1, EPHA2, LTBP2, NOTCH3, NT-proBNP, PDGFRA, SCARF2, THBS2, THBS4, TIMP1, VCAM1, Brown protein cluster

Participants < median age

60 (4)

NT-proBNP

  1. a Estimated using linear regression with robust variance, adjusting for field center, sociodemographics, smoking, cardiovascular risk factors, and renal function.
  2. Bold indicates protein × continuous age interaction with an FDR < 0.05 evaluated at exam 5 (2010–2012, median age 67 years). Brown protein cluster comprises 42 proteins and is described in Fig. 3. Complete modeling results can be found in Supplementary Tables S11 and S12.
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