Fig. 2: Physiological volumetric bone mineral density (vBMD) and microarchitecture assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) in myelofibrosis before and after allo-HSCT.

a Representative axial slice of HR-pQCT-derived image of the distal radius and distal tibia before (Pre-HSCT) and one year after allo-HSCT (Post-HSCT). b Radial total vBMD (Tt.vBMD) of myelofibrosis patients before allo-HSCT (Pre, n = 57) and after allo-HSCT (Post, n = 24), along with the control group (Ctrl, n = 57). On the right, only patients with individual courses (connected by lines, n = 10) are shown. c Tibial Tt.vBMD of the three groups (Pre, n = 57; Post, n = 23; Ctrl, n = 57) and individual patient courses (n = 9). d Radial bone volume to tissue volume (BV/TV) of the three groups (Pre, n = 57; Post, n = 24; Ctrl, n = 57) and individual patient courses (n = 10). e Tibial BV/TV of the three groups (Pre, n = 57; Post, n = 23; Ctrl, n = 57) and individual patient courses (n = 9). f Radial cortical thickness (Ct.Th) of the three groups (Pre, n = 57; Post, n = 24; Ctrl, n = 57) and individual patient courses (n = 10). g Tibial Ct.Th of the three groups (Pre, n = 57; Post, n = 23; Ctrl, n = 57) and individual patient courses (n = 9). The median (center line, 50th percentile) and interquartile range (box edges, 25th–75th percentile) with whiskers extending to the minimum and maximum values are depicted. Each data point is shown. Differences between the three groups were calculated using one-way ANOVA with Holm-Šidák test (b–g). Differences for the individual courses of patients (Pre and Post, connected points) were calculated using two-tailed paired t test (b–f) or Wilcoxon signed-rank test (g) for normally and non-normally distributed data, respectively. Exact p-values of the comparisons are displayed above the brackets and numbers in bold indicate statistical significance (p < 0.05). Source data are provided as a Source Data file.