Fig. 5: PRDX1 suppresses hepatic STAT1 and STAT3 phosphorylation. | Nature Communications

Fig. 5: PRDX1 suppresses hepatic STAT1 and STAT3 phosphorylation.

From: Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice

Fig. 5

a Western blotting of the oxidation of hepatic protein tyrosine phosphatases (PTPs) in WT mice after NC or WD for 20 weeks. n = 4 mice per group. b Western blotting of the oxidation of hepatic PTPs in WT mice after NC or MCD for 2 weeks. n = 4 mice per group. c Western blotting and quantitation of hepatic STAT1 and STAT3 phosphorylation (as in a). n = 4 mice per group. d Western blotting and quantitation of hepatic STAT1 and STAT3 phosphorylation (as in b). n = 4 mice per group. e Western blotting and quantitation of hepatic STAT1 and STAT3 phosphorylation in MCD-fed WT and Prdx1-/- mice. n = 4 mice per group. f Western blotting and quantitation of hepatic STAT1 and STAT3 phosphorylation in WD-fed WT and Alb-Cre;Prdx1fl/fl mice. n = 3 mice per group. g Western blotting and quantitation of hepatic STAT1 and STAT3 phosphorylation in WD-fed WT and Prdx1OE/OE mice. n = 4 mice per group. All the data are presented as means ± SEM. Unpaired and two-tailed Student’s t test was performed for c–g.

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