Fig. 8: Nucleotide-driven structural conversions in KRAS versus MRAS. | Nature Communications

Fig. 8: Nucleotide-driven structural conversions in KRAS versus MRAS.

From: The small GTPase MRAS is a broken switch

Fig. 8

Structural comparison of GDP- and GMPPNP-loaded HRAS (left panels) and MRAS (right panels), focusing on flexibility of the p-loop, switch 1 and switch 2 regions. Putty representations for HRAS-GMPPNP (PDBid: 5P21) and MRAS-GMPPNP (PDBid: 1X1S) are colored by crystallography B-factors (blue=rigid to red=flexible). Ribbons diagrams are overlays of GDP- and GMPPMP-bound proteins with three simulated steps to represent motion. MRAS switch 2 residues 69-73 have no electron density.

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