Fig. 8: Schematic illustration of the mechanism by which endothelium-derived AGGF1 attenuates ischaemic retinopathy. | Nature Communications

Fig. 8: Schematic illustration of the mechanism by which endothelium-derived AGGF1 attenuates ischaemic retinopathy.

From: Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling

Fig. 8

Endothelial AGGF1 deficiency ameliorates pathological angiogenesis in an OIR model. Mechanistically, AGGF1 expression in HRMECs is regulated by retinal hypoxia caused by pathological changes. Our study also suggests an action model through which AGGF1 promotes angiogenesis by activating the cell cycle via the AGGF1/TNFSF12/FN14 signalling pathway. Thus, we speculate that targeting the AGGF1/TNFSF12/FN14 signalling pathway could provide a therapy for the treatment of ischaemic retinopathy.

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