Fig. 2: General response of the clinical outcomes during the study. | Nature Communications

Fig. 2: General response of the clinical outcomes during the study.

From: A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial

Fig. 2

Changes from baseline in (A) HbA1c, (B) fasting glucose, (C) insulin, (D) HOMA-IR, (E) LDL-C, (F) HDL-C, (G) TC, (H) TC/HDL-C ratio and (I) TG during the intervention are shown. Data presented as percent changes from week 0 (mean ± standard error). #q (Treatment×Time) < 0.05 denote p-adjusted values for the Treatment × Time interaction coefficient in the LMM model (two-sided; HbA1c: 0.04; LDL-C: W4 0.02; HDL-C: W4 0.02, W8 0.03, W12 0.01, W16 0.01; TC: W4 0.02); *q (Time) < 0.05, **q (Time) < 0.01, and ***q (Time) < 0.001 denote p-adjusted values for the time coefficient within the same group. p-values were adjusted for multiple hypothesis testing using the Benjamini-Hochberg procedure. Number of participants in IG over weeks: week 0, n = 63; week 4, n = 58; week 8, n = 57; week 12, n = 57; week 16, n = 57; number of participants in CG over weeks: week 0, n = 64; week 4, n = 61; week 8, n = 60; week 12, n = 59; week 16, n = 60. HbA1c: glycated hemoglobin A1c; HOMA-IR: Homeostatic Model Assessment of Insulin Resistance; LDL-C: Low-Density Lipoprotein Cholesterol; HDL-C: High-Density Lipoprotein Cholesterol; TC: Total Cholesterol; TG: Triglycerides.

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