Fig. 7: Mediation analysis identifies linkages between the species, metabolites and blood biomarkers. | Nature Communications

Fig. 7: Mediation analysis identifies linkages between the species, metabolites and blood biomarkers.

From: A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial

Fig. 7

A Parallel coordinates chart showing the 33 mediation effects of the fecal metabolites that were significant at q < 0.05. Shown are taxonomy (left), fecal metabolites (middle) and clinical outcomes (right). The curved lines connecting the panels indicate the mediation effects, with colors corresponding to different metabolites. B Mediation effect of some highlighted fecal metabolites on the levels of HbA1c and TC. C Parallel coordinates chart showing the 14 mediation effects of the plasma metabolites that were significant at q < 0.05. Shown are taxonomy (left), plasma metabolites (middle) and clinical outcomes (right). The curved lines connecting the panels indicate the mediation effects, with colors corresponding to different metabolites. D Mediation effect of some highlighted plasma metabolites on the levels of LDL-C and TC. For (B) and (D), the grey lines indicate the associations between the two factors, with corresponding LMM coefficients and q-values. Direct mediation is shown by a red arrow and reverse mediation is shown by a blue arrow. Corresponding q-values from mediation analysis are shown. See Supplementary Data 1 for full names of metabolite abbreviations and HMDB numbers.

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