Fig. 3: L. reuteri ZJ617 changes microbial function of HFD-fed mice.
From: Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine
a Bar chart represents functional pathways in intestinal contents predicted using PICRUSt2. The pathways enriched in L. reuteri ZJ617 are marked as red panels, and pathways enriched in HFD are marked as blue panels. The polyamine pathways are marked with red fonts. b The key enzymes involved in polyamine biosynthesis. c The prediction of polyamine transport system. d Occurrence of homologous proteins responsible for polyamine synthesis upregulated by L. reuteri ZJ617 in the gut microbiota by BlastP analysis. e Graphical representation of the polyamine biosynthetic pathway. The enzymes marked as green-colored indicated an increase in L. reuteri ZJ617-treated mice, and black-colored symbols indicated no significant changes. 4.1.1.19, arginine decarboxylase; 4.1.1.17, ornithine decarboxylase; 3.5.3.11, agmatinase; 4.1.1.96, coxynorspermidine decarboxylase; 4.1.1.50, S-adenosylmethionine decarboxylase; 2.5.1.16, spermidine synthase. 2.5.1.22 spermine synthase. Significance is calculated using two-tailed Wilcox tests (n = 9 per group).
