Fig. 6: Microbial production of spermidine ameliorates MetS in HFD-fed mice.
From: Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine
HFD-fed mice were supplemented with freshly prepared drinking water, L. reuteri ZJ617 (109 CFU/mL) or spermidine (20 mg/kg). Half of the mice were treated on L. reuteri ZJ617 were orally gavaged with DA (2.5 mg/kg) every day (n = 9 per group). a Study design of spermidine supplement experiment. The figure is drawn by Adobe Illustrator CC 2018. b Body weights and c body weight gains of the above four groups of mice. d Triglycerides. e Total cholesterol. f LDL-C levels in serum. g Blood glucose tolerance measured by OGTT (left) and AUC (right). h Insulin tolerance measured by ITT (left) and AUC (right). i Liver weights. j Liver triglycerides. k Representative H&E pictures of the liver (scale bars, 200 μm). Data were shown as mean ± SD. Significance is calculated based on one-way ANOVA with Å Ãdák tests for multiple-group comparisons. Source data are provided as a Source Data file.
