Table 2 The hazard ratio for incident atherosclerotic cardiovascular disease associated with genetic risk for hypertensive disorders of pregnancy in women from the UK Biobank

From: Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy

 

HR per SD increase (95% CI)

Low genetic risk ( < 20%)

Intermediate genetic risk (20–80%)

High genetic risk (80–99%)

Very high genetic risk ( > 99%)

Total no. of participants

–

32,900

98,700

31,255

1645

No. of incident ASCVD cases

–

1318

4617

1560

103

Incidence rate per 1000 person-years (95% CI)

–

3.52 (3.33–3.72)

4.15 (4.03–4.27)

4.46 (4.24–4.69)

5.66 (4.62–6.87)

Model 1

     

HR (95% CI)

1.09 (1.07–1.12)

1 (reference)

1.16 (1.09–1.24)

1.23 (1.14–1.32)

1.53 (1.25–1.87)

P-value

3.01E-14

–

1.31E-06

3.59E-08

3.15E-05

Model 2

     

HR (95% CI)

1.08 (1.06–1.11)

1 (reference)

1.19 (1.11–1.28)

1.21 (1.11–1.30)

1.58 (1.27–1.97)

P-value

4.12E-10

–

1.41E-06

7.18E-06

4.30E-05

Model 3

     

HR (95% CI)

1.08 (1.05-1.11)

1 (reference)

1.18 (1.10–1.27)

1.20 (1.10–1.30)

1.58 (1.27–1.96)

P-value

2.47E-09

–

2.21E-06

2.34E-05

4.68E-05

Model 4

     

HR (95% CI)

1.06 (1.04–1.09)

1 (reference)

1.16 (1.08–1.25)

1.15 (1.05–1.25)

1.47 (1.18–1.83)

P-value

1.83E-06

–

2.87E-05

1.31E-03

5.82E-04

  1. The hazard ratios were estimated using Cox proportional hazards models. P-values were determined using a two-sided Wald test.
  2. Model 1 was adjusted by HDP of history, age, body mass index, smoking status, genotype array, and genetic PCs 1 to 10.
  3. Model 2: Model 1 + medical condition (systolic blood pressure, diastolic blood pressure, Total cholesterol, HDL cholesterol, LDL cholesterol, Triglycerides, Creatinine, eGFR, Fasting blood glucose, and HbA1c).
  4. Model 3: Model 2 + prevalent metabolic disease (hypertension, diabetes mellitus, and dyslipidemia).
  5. Model 4: Model 3 + medication (aspirin, antihypertensive, and cholesterol medications).
  6. ASCVD atherosclerotic cardiovascular disease, HDP hypertensive disorders of pregnancy, HR hazard ratio, CI confidence interval, SD standard deviation, PC principal component.
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