Fig. 5: Number of participants needed in future trials to achieve 25%, 35% or 50% post-treatment control (<50 copies/mL) among early-ART and late-ART individuals at day 84 of ATI. | Nature Communications

Fig. 5: Number of participants needed in future trials to achieve 25%, 35% or 50% post-treatment control (<50 copies/mL) among early-ART and late-ART individuals at day 84 of ATI.

From: Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: an individual data-based meta-analysis of 24 prospective studies

Fig. 5

Power calculations to be use for future study designs on how many participants would be needed for either single arm or 1:1 active intervention:placebo randomized controlled trials (RCTs) with 2 groups based on the assumption that the studies would have a power of 90% to detect the indicated differences in post-treatment control (PTC) at a 5% significant level, one-sided. Early-ART (a) and late-ART (b) defined as people who started ART within or beyond 6 months of HIV acquisition. ART antiretroviral therapy, ATI ART interruption, PTC post-treatment control.

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