Fig. 1: Syngap1 expression promotes perceptual learning in response to a passive tactile stimulus.

a Schematic of the whisker-dependent instrumental learning paradigm (WDIL), including single whisker detection task structure and response outcomes with go trials being discriminated by single whisker deflection for 3 different whisker stimulus intensities (~400, 650 and 900 °/s). During the WDIL task there was no auditory cue. The noise generated by the piezo during the Go and NoGo trial was masked by 70 dB white noise. b Fraction of total trials correct during WDIL for 3 different whisker stimulus intensities: ~400°/s (wt: blue, n = 9 and Syngap1^+/-: +/−, red, n = 10), 650°/s (wt: blue, n = 7 and Syngap1^+/-: +/−, red, n = 7) and 900°/s (wt: blue, n = 8 and Syngap1^+/-: +/−, red, n = 8). c Summary schematic of the training phase and the reduced stimulation phase. d False Alarm (FA) and Hit rates for animals that reached criteria and underwent the reduced stimulation phase (pull back) for wildtype (wt: blue, n = 6) and Syngap1^+/- (+/−: red, n = 6). Number of animals per genotype is indicated in parentheses. Shaded areas represent the standard error of the mean (S.E.M.). Mixed-effects model and Two-way RM ANOVA were used. p-value for main effects and interaction are indicated as n.s.: p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001 detailed statistics are provided in Supplementary Table1. Source data are provided as a Source Data file.