Fig. 2: Syngap1 expression promotes perceptual learning in ethologically relevant active sensing paradigms.

a Novel object recognition texture (NOR-T) task structure in which mice are tasked to discriminate between visually identical objects having either 8 or 9 verticals ribs/cm. The light level in the arena is 85 lux. b Exploration time and discrimination index during the testing phase of the NOR-T for wildtype animals performing the task with (n = 10) or without whiskers (n = 10) for objects with 1 verticals ribs/cm difference. c Exploration time and discrimination index during the testing phase of the NOR-T for wildtype (wt, n = 8) and Syngap1^+/- (+/−, n = 6) for objects with 1 verticals ribs/cm difference. d Exploration time and discrimination index during the testing phase of the NOR-T for wildtype (wt, n = 10) and Syngap1^+/- (+/−, n = 10) for objects with 3 verticals ribs/cm difference. Mice with at least 10 sec of cumulative object exploration in the NOR-T were included in the analysis. e Novel Object Recognition (NOR) task structure with exploration time and discrimination index during the testing phase of the NOR for 2 different objects: a stapler and a lock in wildtype (wt, n = 7) and Syngap1^+/- (+/-, n = 10). Mice with at least 30 sec of cumulative object exploration in the NOR were included in the analysis. The number of animals per genotype is indicated in parentheses and white within the bar graph. All statistical tests were 2-sided. Error bars represent the standard error of the mean (S.E.M.). P-value are indicated as n.s.: p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001. Detailed statistics are provided in Supplementary Table 2. Source data are provided as a Source Data file.