Fig. 2: Ligand enabled catalytic asymmetric domino Heck/Tsuji−Trost reaction of flexible vinylic halides with 1,3-Dienes.[a-d]. | Nature Communications

Fig. 2: Ligand enabled catalytic asymmetric domino Heck/Tsuji−Trost reaction of flexible vinylic halides with 1,3-Dienes.[a-d].

From: Enantioselective Heck/Tsuji−Trost reaction of flexible vinylic halides with 1,3-dienes

Fig. 2

a Natural product featuring a cyclic isoprenoid skeleton. b Preliminary attempt. c Screening of chiral ligands. [a] 1a (0.1 mmol), 2a (0.4 mmol), palladium catalyst (10 mol%), ligand (20 mol%), silver salt (0.6 equiv), solvent (0.2 M), Ar, 70 °C, 48 h. [b] Yields are determined by GC analysis using anisole as an internal standard. [c] Isolated yield after flash-column chromatography. [d] Determined by HPLC analysis.

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