Fig. 1: Sequential mechanism for double hexameric MCM loading onto origin DNA. | Nature Communications

Fig. 1: Sequential mechanism for double hexameric MCM loading onto origin DNA.

From: Unidirectional MCM translocation away from ORC drives origin licensing

Fig. 1

A key unresolved question addressed in this study is the essential role of ATP hydrolysis by MCM during loading. OC-MC: ORC-Cdc6-MCM-Cdt1 complex. OCCM: ORC-Cdc6-Cdt1-MCM complex. SH single-loaded MCM hexamer, MO MCM-ORC complex, MOC-MC MCM-ORC-Cdc6-MCM-Cdt1 complex, DH MCM double hexamer.

Back to article page