Fig. 10: Model of telomerase RNP assembly with respect to hTR folding.
From: Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq
hTR exists as a structural ensemble in cells, with a minority population adopting alternative conformations in the t/PK and CR4/5 domains (red). The canonical fold of hTR may be favored by the presence of RNA folding chaperones. hTR molecules adopting the canonical fold are efficiently co-assembled into a functional RNP, whereas hTR molecules in the alternative conformation(s) are not efficiently assembled in the RNP complex or are slowly degraded.
