Fig. 3: Population average DMS reactivity of the hTR CR4/5 domain.
From: Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq
a Normalized DMS reactivity of hTR CR4/5 domain (nt. 235–336, n = 4 biological replicates). Intensity of DMS reactivity colored according to the provided legend. Data are presented as means ± SD, open circles representing individual replicate values. Blue arcs designate the base pairing pattern of the canonical t/PK conformation seen by cryo-EM of assembled telomerase. b Secondary structure of the canonical CR4/5 conformation with DMS reactivity of the hTR population average overlaid onto the nucleotides. c DMS reactivity overlaid onto the cryo-EM model of assembled telomerase. PDB 7BG9. Source data are provided as a Source Data file.
