Fig. 9: DREEM-deconvoluted DMS profiles and structure predictions of hTR CR4/5 from telomerase RNP complexes assembled in cells and purified via the FLAG-tag on hTERT.
From: Telomerase RNA structural heterogeneity in living human cells detected by DMS-MaPseq
a Normalized DMS reactivity profiles of the two clusters predicted by DREEM. Intensity of DMS reactivity colored according to the provided legend. Blue arcs designate the base pairing pattern of the data-guided predicted CR4/5 secondary structure. b Data-guided secondary structure prediction of the two clusters with overlaid DMS reactivities. The major and minor clusters have identical structures. Intensity of DMS reactivity colored according to the provided legend.
