Fig. 1: A typical dietary intervention study design.
From: Predicting metabolite response to dietary intervention using deep learning
Before the dietary intervention, the baseline gut microbial compositions and metabolomic profiles (of either fecal samples or blood samples) are measured. During the dietary intervention, one or a few dietary resources are introduced (represented here by avocado) in addition to the baseline diet. The task we intend to solve is to predict personalized metabolite responses after dietary intervention based on the baseline gut microbial compositions, baseline metabolomic profiles, and the dietary intervention strategy.
