Fig. 6: Applying sensitivity analysis of McMLP accurately infers food-microbe consumption interactions and microbe-metabolite production interactions in both synthetic and real data.
From: Predicting metabolite response to dietary intervention using deep learning
a The sensitivity of the relative abundance of species \(i\) to the supplied dietary resource \(\alpha\) is denoted as siα. It is defined as the ratio between the change in the relative abundance of species \(i\) (\({\Delta y}_{i}\)) and a small perturbation in the supplied dietary resource \(\alpha\) (\({\Delta x}_{\alpha }\)). Similarly, the sensitivity of the concentration of metabolite \(\beta\) to the relative abundance of species \(i\) is denoted as sβi. It is defined as the ratio between the change in the concentration of metabolite \(\beta\) (\({\Delta y}_{\beta }\)) and the perturbation in the relative abundance of species \(i\) (\({\Delta x}_{i}\)). b The sensitivity values for food-microbe consumption interactions (colored in green) and microbe-metabolite production interactions (colored in red) in the synthetic data. c The ground-truth food-microbe consumption rates (colored in green) and microbe-metabolite production rates (colored in red) in the synthetic data. d The Area Under the Receiver Operating Characteristic (AUROC) curve based on True Positive (TP) rates and False Positive (FP) rates which are obtained by using different sensitivity thresholds to classify interactions. e The sensitivity values for avocado-microbe consumption interactions (colored in green) and microbe-metabolite production interactions (colored in red) for the real data from the avocado intervention study. f The avocado-microbe-butyrate tripartite graph constructed based on the sensitivity values of avocado-microbe consumption interactions and microbe-butyrate production interactions for the real data from the avocado intervention study. The edge width and edge arrow sizes are proportional to the absolute values of the sensitivities. All microbes in the middle layer are arranged from left to right in the increasing order of the incoming edge width multiplied by the outgoing edge width. Source data are provided as a Source Data file.
